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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CTPS All Species: 29.39
Human Site: S568 Identified Species: 49.74
UniProt: P17812 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.15
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P17812 NP_001896.2 591 66690 S568 L S P R D T Y S D R S G S S S
Chimpanzee Pan troglodytes XP_524681 591 66712 S568 L S P R D T Y S D R S G S S S
Rhesus Macaque Macaca mulatta XP_001084608 591 66746 S568 L S P R D T Y S D R S G S S S
Dog Lupus familis XP_537968 586 65447 S531 Q F H P E F S S R P L K P S P
Cat Felis silvestris
Mouse Mus musculus P70698 591 66664 S568 L S P R D T Y S D R S G S S S
Rat Rattus norvegicus Q5U2N0 586 65655 L543 P S P P Y L G L L L A A T G T
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506472 591 66548 S568 L S P R D T Y S D R S G S S S
Chicken Gallus gallus Q5F3Z1 586 66050 S531 Q F H P E F S S R P M K P S P
Frog Xenopus laevis Q5XHA8 591 66854 S568 L S P R D T Y S D R S E N S S
Zebra Danio Brachydanio rerio Q6PEI7 591 66577 S568 L S P R D A Y S D R S G S S S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VUL1 627 69429 D568 L S P R Q L S D A S S D E E D
Honey Bee Apis mellifera XP_624223 604 67926 D569 L S P Q A I S D N E S D N E C
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P28274 579 64692 S540 Q Y H P E Y T S K V L D P S K
Red Bread Mold Neurospora crassa Q7RZV2 568 63157 A541 F L G F V A A A I G C L D Q I
Conservation
Percent
Protein Identity: 100 99.6 99.4 75.3 N.A. 97.8 74.1 N.A. 94.7 76.9 89.1 86.6 N.A. 63.3 65.5 N.A. N.A.
Protein Similarity: 100 99.8 99.8 85.2 N.A. 98.3 85.1 N.A. 97.1 87.6 95.5 92.8 N.A. 77 79.1 N.A. N.A.
P-Site Identity: 100 100 100 13.3 N.A. 100 13.3 N.A. 100 13.3 86.6 93.3 N.A. 33.3 26.6 N.A. N.A.
P-Site Similarity: 100 100 100 20 N.A. 100 33.3 N.A. 100 20 93.3 93.3 N.A. 33.3 46.6 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 57.1 51.7
Protein Similarity: N.A. N.A. N.A. N.A. 72.5 68.1
P-Site Identity: N.A. N.A. N.A. N.A. 13.3 0
P-Site Similarity: N.A. N.A. N.A. N.A. 20 6.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 8 15 8 8 8 0 8 8 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 8 % C
% Asp: 0 0 0 0 50 0 0 15 50 0 0 22 8 0 8 % D
% Glu: 0 0 0 0 22 0 0 0 0 8 0 8 8 15 0 % E
% Phe: 8 15 0 8 0 15 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 8 0 0 0 8 0 0 8 0 43 0 8 0 % G
% His: 0 0 22 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 8 0 0 8 0 0 0 0 0 8 % I
% Lys: 0 0 0 0 0 0 0 0 8 0 0 15 0 0 8 % K
% Leu: 65 8 0 0 0 15 0 8 8 8 15 8 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 8 0 0 0 15 0 0 % N
% Pro: 8 0 72 29 0 0 0 0 0 15 0 0 22 0 15 % P
% Gln: 22 0 0 8 8 0 0 0 0 0 0 0 0 8 0 % Q
% Arg: 0 0 0 58 0 0 0 0 15 50 0 0 0 0 0 % R
% Ser: 0 72 0 0 0 0 29 72 0 8 65 0 43 72 50 % S
% Thr: 0 0 0 0 0 43 8 0 0 0 0 0 8 0 8 % T
% Val: 0 0 0 0 8 0 0 0 0 8 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 8 0 0 8 8 50 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _